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한의과대학

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연구성과

총 33편의 연구논문 국제저명 SCI저널 게재 (2000-현재)
  • Cho MK, Kim WD, Ki SH, Hwang JI, Choi S, Lee CH, Kim SG. (2007) Role of G{alpha}12/G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor. Mol Cell Biol. 2007 Jun 25 [Epub ahead of print] (impact factor: 6.7)
  • SI Gum, SJ J, SH Ahn, SG Kim, JT Kim, HM Shin and MK Cho (2007) The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[a]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs. J. Ethnopharmacology 112: 568-576. (impact factor: 1.6)
  • MK Cho, SH Suh, CH Lee and SG Kim (2005) Bovine type I collagen inhibits Raw264.7 cell proliferation through phosphoinositide 3-kinase- and mitogen-activated protein kinase-dependent down- regulation of cyclins D1, A and B1. Biochim. Biophys. Acta 1744(1):47-57. (Impact factor: 3.594)
  • (Book chapter) Kim SG, Choi SY, Cho MK and Kang KW (2005)The role of Galpha12 proteins in the PKC and JNK-dependent induction of NOS by thrombin. Oxidative Stress, Inflammation, and Health (Eds: Surh YJ and Pecker L), Taylor & Francis, Chapter 8, pp. 193-205.
  • Cho MK, Jang YP, Kim YC, Kim SG (2004) Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition. Int Immunopharmacol. 4(10-11):1419-29. (Impact factor: 1.655)
  • MK Cho, GH Lee, EY Park, and SG Kim (2004) Hyaluronic acid inhibits adhesion of hepatic stellate cells in spite of its stimulation of DNA synthesis. Tissue & Cell 36(5):293-305. (Impact factor: 0.808)
  • MK Cho, YH Cho, GH Lee, SG Kim (2004) Induction of Cyclooxygenase-2 by Bovine Type I Collagen in Macrophages via C/EBP amd CREB Activation by Multiple Cell Signaling Pathways. Biochemical Pharmacology 67(12):2239-50 (Impact factor: 3.340)
  • M.K. Cho and SG Kim (2003) Phosphatidylinositol 3-Kinase-Dependent Activation of CCAAT Enhancer Binding Protein and Cell Replication by Hepatocyte Growth Factor. Hepatology 37(3):686-695. (Impact factor: 9.825)
  • Cho M.K., Sung M.A., Kim D.S., Park H.K., Jew S.S. and Kim, S.G. (2003) 2-Oxo-3,23-isopropylidene- asiatate (AS2006A), a wound-healing asiatate derivative, exerts anti-inflammatory effect by apoptosis of macrophages. Int Immunopharmacol., 3/10-11:1429-1437. (Impact factor: 1.655)
  • Kim S.C., Cho M.K. and Kim, S.G. (2003) Cadmium-induced non-apoptotic cell death mediated by oxidative stress under the condition of sulfhydryl deficiency. Toxicol. Lett. 144(3):325-336. (Impact factor: 2.242)
  • Kang KW, Choi SY, Cho MK, Lee CH and Kim S.G. (2003) Thrombin induces nitric oxide synthase via Galpha12/13-coupled PKC-dependent I- kB phosphorylation and JNK-mediated I-kB degradation. J. Biol. Chem. 278(19):17368-17378. (Impact factor: 6.696)
  • N.D. Kim, E.M. Kim, K.W. Kang, M.K. Cho, S.Y. Choi and S.G. Kim (2003) Ginsenoside Rg3 Inhibits Phenylephrine-Induced Vascular Contraction through Induction of Nitric Oxide Synthase. British J. Pharmacol. 140(4):661-670. (Impact factor: 3.45)
  • K.W. Kang, Y.G. Kim, M.K. Cho, S.K. Bae, C.W. Kim, M.G. Lee and S.G. Kim (2002) Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation. FASEB J. express article 10.1096/fj.02-0406fje. (Published online October 17, 2002) (Impact factor: 7.252)
  • M.K. Cho, Y.P.Jang, Y.C. Kim and S.G. Kim (2002) Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kB phosphorylation and of p65 nuclear translocation in macrophages. International Immunopharmacology 2(1):105-116. (impact factor: 1.655)
  • M.K Cho, S.H. Suh, and S.G. Kim (2002) JunB/AP-1 and NF-kB-mediated induction of nitric oxide synthase by bovine type I collagen in serum-stimulated murine macrophages. Nitric Oxide-Biology and Chemistry. 6(3), 319-332. (impact factor:2.225)
  • A.K. Lee, K.W. Kang, Y.G. Kim, M.K. Cho, M.G. Lee, C.K. Shim, S.J. Chung and S.G. Kim (2002) Identification of genes enhanced by protein-calorie malnutrition by differential display polymerase chain reaction (expression of fibrinogen B beta chain, B cell translocation gene1 and thyroid hormone responsive protein genes). Molecular and Cellular Biochemistry 231, 163-171.(impact factor: 2.054)
  • Y.G. Kim, M.K. Cho, J.W. Kwon, S.G. Kim, S.J. Chung, C.K. Shim and M.G. Lee (2002) Effects of cysteine on the pharmacokinetics of intravenous chlorzoxazone in rats with protein-calorie malnutrition. Biopharm. Drug Dispos.23(3), 121-129. (impact factor: 0.819)
  • Y.C. Kim, Y.G. Kim, E.J. Kim, M.K. Cho, S.G. Kim and M.G. Lee (2003) Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: effects of food intakes. Biopharm. Drug Dispos. 24(2):53-61. (impact factor: 0.819)
  • K.W. Kang, M.K. Cho, C.H. Lee and S.G. Kim, (2001) Activation of phosphatidylinositol 3-kinase and Akt by tert-Butylhydroquinone (t-BHQ) is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE Cells. Mol. Pharmacol. 59, 1147-1156. (impact factor: 5.678)
  • Y.G. Kim, M.K. Cho, J.W. Kwon, S.G. Kim, S.J Chung, C.K Shim and M.G. Lee (2001) Effects of cysteine on the pharmacokinetics of intravenous phenytoin in rats with protein-calorie malnutrition. Int. J. Pharm. 229(1-2), 45-55. (impact factor: 1.024)
  • Y.C. Kim, M.K. Cho, J.W. Kwon, S.G. Kim, S.H. Kim and M.G. Lee (2001) Effects of cysteine on the pharmacokinetics and pharmacodynamics of intravenous and oral azosemide in rats with protein- calorie malnutrition. Life Sciences 68, 2329-2345. (impact factor: 1.808)
  • H.C. Chung, M.K. Cho, M.H. Sohn, K.W. Kang, S.H. Choi, H.J. Kim, A.K. Lee, H.G. Park, S.S. Jew and S.G. Kim (2000) General pharmacology of AS2-006A, a new wound healing agent. Journal of Toxicology and Public Health 16(3), 211-219.
  • Y.G. Kim, M.K. Cho, J.W.Kwon, S.G. Kim, M.G. Lee (2000) Effects of cysteine on the pharmacokinetics of intravenous adriamycin in rats with protein-calorie malnutrition. Res.Commun. Mol. Pathol. Pharmacol. 107(5-6), 361-376. (impact factor: 0.495)
  • M.K. Cho, Y.G. Kim, M.G. Lee and S.G. Kim (2000) Prevention of c-Jun/activator protein-1 activation and microsomal epoxode hydrolase induction in the rat liver by cysteine during protein-calorie malnutrion. Biochem. Pharm. 61(1), 15-24. (impact factor: 3.542)
  • M.K. Cho, Y.G. Kim, M.G. Lee and S.G. Kim (2000) The effect of cysteine on the altered expression of class α and μ glutathione S-transferase genes in the rat liver during protein-calorie malnutrition. Biochim. Biophys. Acta. 1502,235-246. (impact factor: 3.594)
  • M.K. Cho and S.G. Kim (2000) Enhanced expression of rat hepatic microsomal epoxide hydrolase by methylthiazole in conjunction with liver injury. Toxicology 146(2-3), 111-122. (impact factor: 2.47)
  • M.K. Cho and S.G. Kim (2000) Induction of class α glutathione S-transferase by methylthiazoles in the rat liver: role of oxidative stress. Toxicol. Lett. 115(2), 107-115. (impact factor: 2.242)

특허

  • 01황함유 아미노산 또는 그 유도체의 약물대사효소의 이상발현 및 변화된 약물동력학 교정용 용도 및 미 황함유 아미노산 또는 그 유도체를 유효성분으로 함유하는 약학적 조성물, Korean Patent No. 98-39975 (1998-9- 25), patent number1003774300000 (2002.12.24 등록)
  • 02독성물질 흡착효능을 갖는 위장관 질환 예방 및 치료용 생약 미립구, 그제조 방법 및 이를 포함한 약학조성물 및 건강 보조식품. (2001) 대한민국 특허출원 (제 10-2001-0012540) patent number 10-04714640000 (2005.01.17 등록)
  • 03유기용매흡착성 생약 미립구를 포함하는 숙취경감용 약학 조성물 및 건강 보조식품. (2001) 대한민국 특허출원 (제 10-2001-0012533). patent number 10-04460610000 (2004.08.18 등록)
  • 04A herbal mixture extract of Adenophora tripylla, Acanthopanax sessilitlorous, Gingko nut, Hovenia dulcis, Seacucumber, Abalone, Allium tuberosum, Semisulcospira libertina, Ginger and Glycyrrhizae radix, and food supplement comprising the same for prevention and treatment of liver disease (2006) 대한민국 (10-2006-0224509-24)
  • 05A herbal mixture extract comprising Pinellia termate, Atractylodis Rhizoma Alba, Gastrodia elata, Aurantii nobilis pericarpium, Poria cocos, Crataegur, Siegesbeckia glabrescens Makino, Coptis Rhizoma and pharmaceutical composition comprising the same for prevention and treatment of Arteriosclerosis (2006) Korea (10-2006-0050065)
  • 06A herbal mixture extract comprising Atractylodis Rhizoma Alba, Gastrodia elata, Aurantii nobilis pericarpium, Poria cocos, Crataegur, Siegesbeckia glabrescens Makino and food supplement comprising the same for prevention and treatment of Arteriosclerosis (2006) Korea (10-2006-0050066)
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